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Immunological and Inflammatory Aspects of Periodontal Disease

Course Number: 1

References / Additional Resources

  1. Delves PJ, Roitt IM. The immune system. First of two parts. N Engl J Med. 2000 Jul 6;343(1):37-49.

  2. Delves PJ, Roitt IM. The immune system. Second of two parts. N Engl J Med. 2000 Jul 13;343(2):108-117.

  3. Medzhitov R, Janeway C Jr. Innate immunity. N Engl J Med. 2000 Aug 3;343(5):338-344.

  4. Klein J, Sato A. The HLA system. First of two parts. N Engl J Med. 2000 Sep 7;343(10):702-709.

  5. von Andrian UH, Mackay CR. T-cell function and migration. Two sides of the same coin. N Engl J Med. 2000 Oct 5;343(14):1020-1034.

  6. Kamradt T, Mitchison NA. Tolerance and autoimmunity. N Engl J Med. 2001 Mar 1;344(9):655-664.

  7. Walport MJ. Complement. First of two parts. N Engl J Med. 2001 Apr 5;344(14):1058-1066.

  8. Walport MJ. Complement. Second of two parts. N Engl J Med. 2001 Apr 12;344(15):1140-1144.

  9. Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol 2000. 2005;38:135-187.

  10. Holt SC, Ebersole JL. Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitis. Periodontol 2000. 2005;38:72-122.

  11. Sandros J, Papapanou PN, Nannmark U, Dahlén G. Porphyromonas gingivalis invades human pocket epithelium in vitro. J Periodontal Res. 1994 Jan;29(1):62-69.

  12. Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest. 1976 Mar;34(3):235-249.

  13. Kornman KS, Page RC, Tonetti MS. The host response to the microbial challenge in periodontitis: assembling the players. Periodontol 2000. 1997 Jun;14:33-53.

  14. Dennison DK, Van Dyke TE. The acute inflammatory response and the role of phagocytic cells in periodontal health and disease. Periodontol 2000. 1997 Jun;14:54-78.

  15. Gemmell E, Marshall RI, Seymour GJ. Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease. Periodontol 2000. 1997 Jun;14:112-143.

  16. Cochran DL. Inflammation and bone loss in periodontal disease. J Periodontol. 2008 Aug;79(8 Suppl):1569-1576.

  17. Offenbacher S, Barros SP, Beck JD. Rethinking periodontal inflammation. J Periodontol. 2008 Aug;79(8 Suppl):1577-84. doi: 10.1902/jop.2008.080220.

  18. Graves D. Cytokines that promote periodontal tissue destruction. J Periodontol. 2008 Aug;79(8 Suppl):1585-91. doi: 10.1902/jop.2008.080183.

  19. Reynolds JJ, Meikle MC. Mechanisms of connective tissue matrix destruction in periodontitis. Periodontol 2000. 1997 Jun;14:144-157.

  20. Noguchi K, Ishikawa I. The roles of cyclooxygenase-2 and prostaglandin E2 in periodontal disease. Periodontol 2000. 2007;43:85-101.

  21. Mahanonda R, Pichyangkul S. Toll-like receptors and their role in periodontal health and disease. Periodontol 2000. 2007;43:41-55.

  22. Gemmell E, Yamazaki K, Seymour GJ. The role of T cells in periodontal disease: homeostasis and autoimmunity. Periodontol 2000. 2007;43:14-40.

  23. Serhan CN. Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. J Periodontol. 2008 Aug;79(8 Suppl):1520-6. doi: 10.1902/jop.2008.080231.

  24. Nagasawa T, Kiji M, Yashiro R, et al. Roles of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin in periodontal health and disease. Periodontol 2000. 2007;43:65-84.

  25. Ebersole JL, Dawson DR 3rd, Morford LA, et al. Periodontal disease immunology: 'double indemnity' in protecting the host. Periodontol 2000. 2013 Jun;62(1):163-202. doi: 10.1111/prd.12005.

  26. Dommisch H, Jepsen S. Diverse functions of defensins and other antimicrobial peptides in periodontal tissues. Periodontol 2000. 2015 Oct;69(1):96-110. doi: 10.1111/prd.12093.

  27. Herrmann JM, Meyle J. Neutrophil activation and periodontal tissue injury. Periodontol 2000. 2015 Oct;69(1):111-27. doi: 10.1111/prd.12088.

  28. Zenobia C, Hajishengallis G. Basic biology and role of interleukin-17 in immunity and inflammation. Periodontol 2000. 2015 Oct;69(1):142-59. doi: 10.1111/prd.12083.

  29. Gonzales JR. T- and B-cell subsets in periodontitis. Periodontol 2000. 2015 Oct;69(1):181-200. doi: 10.1111/prd.12090.

  30. Van Dyke TE. Pro-resolving mediators in the regulation of periodontal disease. Mol Aspects Med. 2017;58:21-36. doi:10.1016/j.mam.2017.04.006.

  31. Kotsakis GA, Olmedo DG. Peri-implantitis is not periodontitis: Scientific discoveries shed light on microbiome-biomaterial interactions that may determine disease phenotype. Periodontol 2000. 2021 Jun;86(1):231-240. doi: 10.1111/prd.12372.

  32. Bamashmous S, Kotsakis GA, Kerns KA, Zenobia C, Chen D, Trivedi HM, McLean JS, Darveau R. Human Variation in Gingival Inflammation. Proceedings of the National Academy of Sciences (PNAS) 2021 [In Press]

Additional Resources

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